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1.What is the TAK-438 ?

Vonoprazan is a selective, reversible, and potassium-competitive proton pump inhibitor that inhibits gastric H+/K+ ATPase (IC50 = 17 nM) but does not inhibit porcine Na+/K+ ATPase activity when used at a concentration of 10 μM. It maintains its inhibitory effect in both weakly acidic (pH 6.5) and neutral (pH 7.5) conditions with IC50 values of 19 and 28 nM, respectively. In vivo, vonoprazan (1, 2, and 4 mg/kg) inhibits histamine-stimulated acid secretion in a dose-dependent manner in rats, with complete inhibition when administered at a dose of 4 mg/kg. It also inhibits acid secretion for more than 48 hours in dogs when administered at doses ranging from 0.1 to 1 mg/kg.

2.What is the CAS number for TAK-438 ?

The CAS number of TAK-438 is 1260141-27-2.

3.What are another words for TAK-438 ?

Synonyms?for?TAK-438 1260141-27-2:5-(2-Fluorophenyl)-N-methyl-1-(3-pyridinylsulfonyl)-1H-pyrrole-3-methanamine 2-butenedioate; fumaric acid;1-[5-(2-Fluorophenyl)-1-(3-pyridylsulfonyl)pyrrol-3-yl]-N-methyl-methanamine; fumaric acid;

4.What is TAK-438 (1260141-27-2) used for?

Vonoprazan Fumarate is a novel potassium-?competitive acid blocker for the treatment of acid-?related diseases.

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5.Buy TAK-438 with the best price .

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